Elsevier Editorial System(tm) for Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Manuscript Draft Manuscript Number: SAA-D-11-01528 Title: Characterization of Solid Polymer Dispersions of Active Pharmaceutical Ingredients by 19F MAS NMR and Factor Analysis
نویسندگان
چکیده
Current pharmaceutical research encounters with the problem of low solubility of many 14 active ingredients (APIs). To overcome this limitation the poorly water-soluble drugs are formulated as 15 solid dispersions in matrices of hydrophilic polymers. In these new dosage formulations, besides the 16 notoriously discussed polymorphism and a bit mysterious pseudopolyamorphism, precise structural 17 characterization of APIs is complicated by their interactions with macromolecules of excipients. In this 18 communication a time-saving method for identification of various forms of pharmaceutical substances 19 in solid polymer dispersions is introduced. The method is demonstrated on a moderately-sized active 20 *Manuscript Click here to view linked References
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